It's been awhile since I have pruned my feed list, with over 200 subscriptions, it was time. I have recently been doing mostly Python work on a Mac. Being a former .NET/Windows only developer, I have a lot of feeds that I no longer am interested in.
Meanwhile, I have found some real treasures that are relevant to my current interests (Python, Apple, Healthcare, Video, Startups, and Small Business). Some of my favorites:
Furthermore, I have switched over to Google Reader and so if you are interested, I share my highlights from my daily (well, periodic with tendencies for the periods to be more than daily) reading here.
The really sweet thing about Google Reader is the interface that exists for the iPhone:
Works fantastically even over the dismal EDGE network.